Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

The influenza virus neuraminidase (NA)-specific inhibitor zanamivir (4-guanidino-Neu5Ac2en) is effective in humans when administered topically within the respiratory tract. The search for compounds with altered pharmacological properties has led to the identification of a novel series of influenza v...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: McKimm-Breschkin, Jennifer L., Sahasrabudhe, Anjali, Blick, Tony J., McDonald, Mandy, Colman, Peter M., Hart, Graham J., Bethell, Richard C., Varghese, Joseph N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 1998
Assuntos:
Animal Viruses
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC109546/
https://ncbi.nlm.nih.gov/pubmed/9499107
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares