Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

The influenza virus neuraminidase (NA)-specific inhibitor zanamivir (4-guanidino-Neu5Ac2en) is effective in humans when administered topically within the respiratory tract. The search for compounds with altered pharmacological properties has led to the identification of a novel series of influenza v...

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Bibliographische Detailangaben
Hauptverfasser: McKimm-Breschkin, Jennifer L., Sahasrabudhe, Anjali, Blick, Tony J., McDonald, Mandy, Colman, Peter M., Hart, Graham J., Bethell, Richard C., Varghese, Joseph N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Animal Viruses
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC109546/
https://ncbi.nlm.nih.gov/pubmed/9499107
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