Mutations in a Conserved Residue in the Influenza Virus Neuraminidase Active Site Decreases Sensitivity to Neu5Ac2en-Derived Inhibitors

The influenza virus neuraminidase (NA)-specific inhibitor zanamivir (4-guanidino-Neu5Ac2en) is effective in humans when administered topically within the respiratory tract. The search for compounds with altered pharmacological properties has led to the identification of a novel series of influenza v...

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Publié dans:	J Virol
Auteurs principaux:	McKimm-Breschkin, Jennifer L., Sahasrabudhe, Anjali, Blick, Tony J., McDonald, Mandy, Colman, Peter M., Hart, Graham J., Bethell, Richard C., Varghese, Joseph N.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Animal Viruses
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC109546/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9499107/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.3.2456-2462.1998
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