The biological function of an insect antifreeze protein simulated by molecular dynamics

Por Kuiper, Michael J, Morton, Craig J, Abraham, Sneha E, Gray-Weale, Angus
Publicado no eLife (2015)

Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis

Por Johnston, Jodie M., Arcus, Vickery L., Morton, Craig J., Parker, Michael W., Baker, Edward N.
Publicado em 2003

Molecular Evolution of Glutathione S-Transferases in the Genus Drosophila

Por Low, Wai Yee, Ng, Hooi Ling, Morton, Craig J., Parker, Michael W., Batterham, Philip, Robin, Charles
Publicado em 2007

Structures of Perfringolysin O Suggest a Pathway for Activation of Cholesterol-dependent Cytolysins

Por Rossjohn, Jamie, Polekhina, Galina, Feil, Susanne C., Morton, Craig J., Tweten, Rodney K., Parker, Michael W.
Publicado em 2007

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA

Por Ascher, David B., Wielens, Jerome, Nero, Tracy L., Doughty, Larissa, Morton, Craig J., Parker, Michael W.
Publicado em 2014

Design of a Conformationally Defined and Proteolytically Stable Circular Mimetic of Brain-derived Neurotrophic Factor

Por Fletcher, Jordan M., Morton, Craig J., Zwar, Richard A., Murray, Simon S., O'Leary, Paul D., Hughes, Richard A.
Publicado em 2008

An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin

Por Wade, Kristin R., Hotze, Eileen M., Kuiper, Michael J., Morton, Craig J., Parker, Michael W., Tweten, Rodney K.
Publicado no Proc Natl Acad Sci U S A (2015)

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

Por McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Preventing serpin aggregation: The molecular mechanism of citrate action upon antitrypsin unfolding

Por Pearce, Mary C., Morton, Craig J., Feil, Susanne C., Hansen, Guido, Adams, Julian J., Parker, Michael W., Bottomley, Stephen P.
Publicado em 2008

Intrasteric control of AMPK via the γ(1) subunit AMP allosteric regulatory site

Por Adams, Julian, Chen, Zhi-Ping, Van Denderen, Bryce J.W., Morton, Craig J., Parker, Michael W., Witters, Lee A., Stapleton, David, Kemp, Bruce E.
Publicado em 2004

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

Por Hermans, Stefan J, Ascher, David B, Hancock, Nancy C, Holien, Jessica K, Michell, Belinda J, Yeen Chai, Siew, Morton, Craig J, Parker, Michael W
Publicado no Protein Sci (2015)

Glutathione transferase P1‐1 as an arsenic drug‐sequestering enzyme

Por Parker, Lorien J., Bocedi, Alessio, Ascher, David B., Aitken, Jade B., Harris, Hugh H., Lo Bello, Mario, Ricci, Giorgio, Morton, Craig J., Parker, Michael W.
Publicado no Protein Sci (2016)

Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation

Por Lawrence, Sara L., Feil, Susanne C., Morton, Craig J., Farrand, Allison J., Mulhern, Terrence D., Gorman, Michael A., Wade, Kristin R., Tweten, Rodney K., Parker, Michael W.
Publicado no Sci Rep (2015)

Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins

Por Lawrence, Sara L., Gorman, Michael A., Feil, Susanne C., Mulhern, Terrence D., Kuiper, Michael J., Ratner, Adam J., Tweten, Rodney K., Morton, Craig J., Parker, Michael W.
Publicado no Structure (2016)

Copper binding to the Alzheimer’s disease amyloid precursor protein

Por Kong, Geoffrey K.-W., Miles, Luke A., Crespi, Gabriela A. N., Morton, Craig J., Ng, Hooi Ling, Barnham, Kevin J., McKinstry, William J., Cappai, Roberto, Parker, Michael W.
Publicado em 2007

Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1

Por Téllez-Sanz, Ramiro, Cesareo, Eleonora, Nuccetelli, Marzia, Aguilera, Ana M., Barón, Carmen, Parker, Lorien J., Adams, Julian J., Morton, Craig J., Lo Bello, Mario, Parker, Michael W., García-Fuentes, Luis
Publicado em 2006

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Por Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Róisín M., Headey, Stephen J., Vazirani, Mansha, Shouldice, Stephen R., Coinçon, Mathieu, Tay, Stephanie, Morton, Craig J., Simpson, Jamie S., Martin, Jennifer L., Scanlon, Martin J.
Publicado no PLoS One (2017)

Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

Por Quesada-Soriano, Indalecio, Parker, Lorien J, Primavera, Alessandra, Casas-Solvas, Juan M, Vargas-Berenguel, Antonio, Barón, Carmen, Morton, Craig J, Paola Mazzetti, Anna, Lo Bello, Mario, Parker, Michael W, García-Fuentes, Luis
Publicado em 2009

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

Por Feil, Susanne C., Hamilton, Stephanie, Krippner, Guy Y., Lin, Bo, Luttick, Angela, McConnell, Darryl B., Nearn, Roland, Parker, Michael W., Ryan, Jane, Stanislawski, Pauline C., Tucker, Simon P., Watson, Keith G., Morton, Craig J.
Publicado em 2012

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

Por Braig, David, Nero, Tracy L., Koch, Hans-Georg, Kaiser, Benedict, Wang, Xiaowei, Thiele, Jan R., Morton, Craig J., Zeller, Johannes, Kiefer, Jurij, Potempa, Lawrence A., Mellett, Natalie A., Miles, Luke A., Du, Xiao-Jun, Meikle, Peter J., Huber-Lang, Markus, Stark, G. Björn, Parker, Michael W., Peter, Karlheinz, Eisenhardt, Steffen U.
Publicado no Nat Commun (2017)