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An intermolecular electrostatic interaction controls the prepore-to-pore transition in a cholesterol-dependent cytolysin
β-Barrel pore-forming toxins (βPFTs) form an obligatory oligomeric prepore intermediate before the formation of the β-barrel pore. The molecular components that control the critical prepore-to-pore transition remain unknown for βPFTs. Using the archetype βPFT perfringolysin O, we show that E183 of e...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4343107/ https://ncbi.nlm.nih.gov/pubmed/25646411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1423754112 |
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