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Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides
Insulin-regulated aminopeptidase (IRAP or oxytocinase) is a membrane-bound zinc-metallopeptidase that cleaves neuroactive peptides in the brain and produces memory enhancing effects when inhibited. We have determined the crystal structure of human IRAP revealing a closed, four domain arrangement wit...
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| Publicado no: | Protein Sci |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BlackWell Publishing Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4315657/ https://ncbi.nlm.nih.gov/pubmed/25408552 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2604 |
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