Targeting virulence not viability in the search for future antibacterials

Por Heras, Begoña, Scanlon, Martin J, Martin, Jennifer L
Publicado no Br J Clin Pharmacol (2015)

Preparation, crystallization and preliminary X-ray diffraction analysis of two intestinal fatty-acid binding proteins in the presence of 11-(dansylamino)undecanoic acid

Por Laguerre, Aisha, Wielens, Jerome, Parker, Michael W., Porter, Christopher J. H., Scanlon, Martin J.
Publicado em 2011

Binding of CFA/I Pili of Enterotoxigenic Escherichia coli to Asialo-GM1 Is Mediated by the Minor Pilin CfaE

Por Madhavan, T. P. Vipin, Riches, James D., Scanlon, Martin J., Ulett, Glen C., Sakellaris, Harry
Publicado no Infect Immun (2016)

The Structural Impact of a Polyglutamine Tract Is Location-Dependent

Por Robertson, Amy L., Horne, James, Ellisdon, Andrew M., Thomas, Bronwen, Scanlon, Martin J., Bottomley, Stephen P.
Publicado em 2008

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

Por McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Small heat-shock proteins interact with a flanking domain to suppress polyglutamine aggregation

Por Robertson, Amy L., Headey, Stephen J., Saunders, Helen M., Ecroyd, Heath, Scanlon, Martin J., Carver, John A., Bottomley, Stephen P.
Publicado em 2010

Distinct binding properties of TIAR RRMs and linker region

Por Kim, Henry S., Headey, Stephen J., Yoga, Yano M.K., Scanlon, Martin J., Gorospe, Myriam, Wilce, Matthew C.J., Wilce, Jacqueline A.
Publicado em 2013

Structure of the Chicken CD3ϵδ/γ Heterodimer and Its Assembly with the αβT Cell Receptor

Por Berry, Richard, Headey, Stephen J., Call, Melissa J., McCluskey, James, Tregaskes, Clive A., Kaufman, Jim, Koh, Ruide, Scanlon, Martin J., Call, Matthew E., Rossjohn, Jamie
Publicado em 2014

Molecular Insights into the Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and an Invasion-Inhibitory Peptide

Por Wang, Geqing, MacRaild, Christopher A., Mohanty, Biswaranjan, Mobli, Mehdi, Cowieson, Nathan P., Anders, Robin F., Simpson, Jamie S., McGowan, Sheena, Norton, Raymond S., Scanlon, Martin J.
Publicado em 2014

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

Por Kurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J., Martin, Jennifer L.
Publicado em 2013

The Structure of Integrin α1I Domain in Complex with a Collagen-mimetic Peptide

Por Chin, Yanni K.-Y., Headey, Stephen J., Mohanty, Biswaranjan, Patil, Rahul, McEwan, Paul A., Swarbrick, James D., Mulhern, Terrence D., Emsley, Jonas, Simpson, Jamie S., Scanlon, Martin J.
Publicado em 2013

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor α in a Ligand-selective Manner

Por Hughes, Maria L. R., Liu, Bonan, Halls, Michelle L., Wagstaff, Kylie M., Patil, Rahul, Velkov, Tony, Jans, David A., Bunnett, Nigel W., Scanlon, Martin J., Porter, Christopher J. H.
Publicado no J Biol Chem (2015)

Fragment library screening identifies hits that bind to the non-catalytic surface of Pseudomonas aeruginosa DsbA1

Por Mohanty, Biswaranjan, Rimmer, Kieran, McMahon, Róisín M., Headey, Stephen J., Vazirani, Mansha, Shouldice, Stephen R., Coinçon, Mathieu, Tay, Stephanie, Morton, Craig J., Simpson, Jamie S., Martin, Jennifer L., Scanlon, Martin J.
Publicado no PLoS One (2017)

The Role of Oxidoreductases in Determining the Function of the Neisserial Lipid A Phosphoethanolamine Transferase Required for Resistance to Polymyxin

Por Piek, Susannah, Wang, Zhirui, Ganguly, Jhuma, Lakey, Adam M., Bartley, Stephanie N., Mowlaboccus, Shakeel, Anandan, Anandhi, Stubbs, Keith A., Scanlon, Martin J., Vrielink, Alice, Azadi, Parastoo, Carlson, Russell W., Kahler, Charlene M.
Publicado em 2014

The Structure of the Bacterial Oxidoreductase Enzyme DsbA in Complex with a Peptide Reveals a Basis for Substrate Specificity in the Catalytic Cycle of DsbA Enzymes

Por Paxman, Jason J., Borg, Natalie A., Horne, James, Thompson, Philip E., Chin, Yanni, Sharma, Pooja, Simpson, Jamie S., Wielens, Jerome, Piek, Susannah, Kahler, Charlene M., Sakellaris, Harry, Pearce, Mary, Bottomley, Stephen P., Rossjohn, Jamie, Scanlon, Martin J.
Publicado em 2009

Conserved features in TamA enable interaction with TamB to drive the activity of the translocation and assembly module

Por Selkrig, Joel, Belousoff, Matthew J., Headey, Stephen J., Heinz, Eva, Shiota, Takuya, Shen, Hsin-Hui, Beckham, Simone A., Bamert, Rebecca S., Phan, Minh-Duy, Schembri, Mark A., Wilce, Matthew C.J., Scanlon, Martin J., Strugnell, Richard A., Lithgow, Trevor
Publicado no Sci Rep (2015)

Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

Por Hildebrand, Joanne M., Tanzer, Maria C., Lucet, Isabelle S., Young, Samuel N., Spall, Sukhdeep K., Sharma, Pooja, Pierotti, Catia, Garnier, Jean-Marc, Dobson, Renwick C. J., Webb, Andrew I., Tripaydonis, Anne, Babon, Jeffrey J., Mulcair, Mark D., Scanlon, Martin J., Alexander, Warren S., Wilks, Andrew F., Czabotar, Peter E., Lessene, Guillaume, Murphy, James M., Silke, John
Publicado em 2014