Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

Pseudomonas aeruginosa is an opportunistic human pathogen for which new antimicrobial drug options are urgently sought. P. aeruginosa disulfide-bond protein A1 (PaDsbA1) plays a pivotal role in catalyzing the oxidative folding of multiple virulence proteins and as such holds great promise as a drug...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr D Biol Crystallogr
Main Authors: McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4667283/
https://ncbi.nlm.nih.gov/pubmed/26627647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004715018519
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