Targeting virulence not viability in the search for future antibacterials

Por Heras, Begoña, Scanlon, Martin J, Martin, Jennifer L
Publicado no Br J Clin Pharmacol (2015)

Characterization of Two Homologous Disulfide Bond Systems Involved in Virulence Factor Biogenesis in Uropathogenic Escherichia coli CFT073

Por Totsika, Makrina, Heras, Begoña, Wurpel, Daniël J., Schembri, Mark A.
Publicado em 2009

Crystal structures of the DsbG disulfide isomerase reveal an unstable disulfide

Por Heras, Begoña, Edeling, Melissa A., Schirra, Horst J., Raina, Satish, Martin, Jennifer L.
Publicado em 2004

The Acidic Nature of the CcmG Redox-Active Center Is Important for Cytochrome c Maturation in Escherichia coli

Por Edeling, Melissa A., Ahuja, Umesh, Heras, Begoña, Thöny-Meyer, Linda, Martin, Jennifer L.
Publicado em 2004

Unraveling the Redox Properties of the Global Regulator FurA from Anabaena sp. PCC 7120: Disulfide Reductase Activity Based on Its CXXC Motifs

Por Botello-Morte, Laura, Bes, M. Teresa, Heras, Begoña, Fernández-Otal, Ángela, Peleato, M. Luisa, Fillat, María F.
Publicado em 2014

Rv2969c, essential for optimal growth in Mycobacterium tuberculosis, is a DsbA-like enzyme that interacts with VKOR-derived peptides and has atypical features of DsbA-like disulfid...

Por Premkumar, Lakshmanane, Heras, Begoña, Duprez, Wilko, Walden, Patricia, Halili, Maria, Kurth, Fabian, Fairlie, David P., Martin, Jennifer L.
Publicado em 2013

Sent packing: protein engineering generates a new crystal form of Pseudomonas aeruginosa DsbA1 with increased catalytic surface accessibility

Por McMahon, Roisin M., Coinçon, Mathieu, Tay, Stephanie, Heras, Begoña, Morton, Craig J., Scanlon, Martin J., Martin, Jennifer L.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

Structure of the Acinetobacter baumannii Dithiol Oxidase DsbA Bound to Elongation Factor EF-Tu Reveals a Novel Protein Interaction Site

Por Premkumar, Lakshmanane, Kurth, Fabian, Duprez, Wilko, Grøftehauge, Morten K., King, Gordon J., Halili, Maria A., Heras, Begoña, Martin, Jennifer L.
Publicado em 2014

Structural and Biochemical Characterization of Chlamydia trachomatis DsbA Reveals a Cysteine-Rich and Weakly Oxidising Oxidoreductase

Por Christensen, Signe, Grøftehauge, Morten K., Byriel, Karl, Huston, Wilhelmina M., Furlong, Emily, Heras, Begoña, Martin, Jennifer L., McMahon, Róisín M.
Publicado no PLoS One (2016)

A Periplasmic Thioredoxin-Like Protein Plays a Role in Defense against Oxidative Stress in Neisseria gonorrhoeae

Por Achard, Maud E. S., Hamilton, Amanda J., Dankowski, Tarek, Heras, Begoña, Schembri, Mark S., Edwards, Jennifer L., Jennings, Michael P., McEwan, Alastair G.
Publicado em 2009

Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor

Por Daly, Norelle L., Thorstholm, Louise, Greenwood, Kathryn P., King, Gordon J., Rosengren, K. Johan, Heras, Begoña, Martin, Jennifer L., Craik, David J.
Publicado em 2013

Laboratory evolution of one disulfide isomerase to resemble another

Por Hiniker, Annie, Ren, Guoping, Heras, Begoña, Zheng, Ying, Laurinec, Stephanie, Jobson, Richard W., Stuckey, Jeanne A., Martin, Jennifer L., Bardwell, James C. A.
Publicado em 2007

Interaction between Plate Make and Protein in Protein Crystallisation Screening

Por King, Gordon J., Chen, Kai-En, Robin, Gautier, Forwood, Jade K., Heras, Begoña, Thakur, Anil S., Kobe, Bostjan, Blomberg, Simon P., Martin, Jennifer L.
Publicado em 2009

The antigen 43 structure reveals a molecular Velcro-like mechanism of autotransporter-mediated bacterial clumping

Por Heras, Begoña, Totsika, Makrina, Peters, Kate M., Paxman, Jason J., Gee, Christine L., Jarrott, Russell J., Perugini, Matthew A., Whitten, Andrew E., Schembri, Mark A.
Publicado em 2014

Characterisation of a cell wall-anchored protein of <it>Staphylococcus saprophyticus </it>associated with linoleic acid resistance

Por King Nathan P, Sakinç Türkan, Ben Zakour Nouri L, Totsika Makrina, Heras Begoña, Simerska Pavla, Shepherd Mark, Gatermann Sören G, Beatson Scott A, Schembri Mark A
Publicado em 2012-01-01

Characterisation of a cell wall-anchored protein of Staphylococcus saprophyticus associated with linoleic acid resistance

Por King, Nathan P, Sakinç, Türkan, Ben Zakour, Nouri L, Totsika, Makrina, Heras, Begoña, Simerska, Pavla, Shepherd, Mark, Gatermann, Sören G, Beatson, Scott A, Schembri, Mark A
Publicado em 2012

Structural and Functional Characterization of Three DsbA Paralogues from Salmonella enterica Serovar Typhimurium

Por Heras, Begoña, Totsika, Makrina, Jarrott, Russell, Shouldice, Stephen R., Gunčar, Gregor, Achard, Maud E. S., Wells, Timothy J., Argente, M. Pilar, McEwan, Alastair G., Schembri, Mark A.
Publicado em 2010

Comparative Sequence, Structure and Redox Analyses of Klebsiella pneumoniae DsbA Show That Anti-Virulence Target DsbA Enzymes Fall into Distinct Classes

Por Kurth, Fabian, Rimmer, Kieran, Premkumar, Lakshmanane, Mohanty, Biswaranjan, Duprez, Wilko, Halili, Maria A., Shouldice, Stephen R., Heras, Begoña, Fairlie, David P., Scanlon, Martin J., Martin, Jennifer L.
Publicado em 2013

Molecular and Structural Characterization of a Novel Escherichia coli Interleukin Receptor Mimic Protein

Por Moriel, Danilo G., Heras, Begoña, Paxman, Jason J., Lo, Alvin W., Tan, Lendl, Sullivan, Matthew J., Dando, Samantha J., Beatson, Scott A., Ulett, Glen C., Schembri, Mark A.
Publicado no mBio (2016)

Properties of the Thioredoxin Fold Superfamily Are Modulated by a Single Amino Acid Residue

Por Ren, Guoping, Stephan, Daniel, Xu, Zhaohui, Zheng, Ying, Tang, Danming, Harrison, Rosemary S., Kurz, Mareike, Jarrott, Russell, Shouldice, Stephen R., Hiniker, Annie, Martin, Jennifer L., Heras, Begoña, Bardwell, James C. A.
Publicado em 2009