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Structural Insights into the Role of the Cyclic Backbone in a Squash Trypsin Inhibitor
MCoTI-II is a head-to-tail cyclic peptide with potent trypsin inhibitory activity and, on the basis of its exceptional proteolytic stability, is a valuable template for the design of novel drug leads. Insights into inhibitor dynamics and interactions with biological targets are critical for drug des...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2013
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3861661/ https://ncbi.nlm.nih.gov/pubmed/24169696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.528240 |
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