Glutathione transferase P1‐1 as an arsenic drug‐sequestering enzyme

Arsenic‐based compounds are paradoxically both poisons and drugs. Glutathione transferase (GSTP1‐1) is a major factor in resistance to such drugs. Here we describe using crystallography, X‐ray absorption spectroscopy, mutagenesis, mass spectrometry, and kinetic studies how GSTP1‐1 recognizes the dru...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Protein Sci
Prif Awduron: Parker, Lorien J., Bocedi, Alessio, Ascher, David B., Aitken, Jade B., Harris, Hugh H., Lo Bello, Mario, Ricci, Giorgio, Morton, Craig J., Parker, Michael W.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2016
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5275733/
https://ncbi.nlm.nih.gov/pubmed/27863446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3084
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