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Glutathione transferase P1‐1 as an arsenic drug‐sequestering enzyme
Arsenic‐based compounds are paradoxically both poisons and drugs. Glutathione transferase (GSTP1‐1) is a major factor in resistance to such drugs. Here we describe using crystallography, X‐ray absorption spectroscopy, mutagenesis, mass spectrometry, and kinetic studies how GSTP1‐1 recognizes the dru...
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| Veröffentlicht in: | Protein Sci |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
John Wiley and Sons Inc.
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5275733/ https://ncbi.nlm.nih.gov/pubmed/27863446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3084 |
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