A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we probed the role of glutathione transferase (...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2019
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628828/
https://ncbi.nlm.nih.gov/pubmed/31221747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903297116
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