A structure-based mechanism of cisplatin resistance mediated by glutathione transferase P1-1

Cisplatin [cis-diamminedichloroplatinum(II) (cis-DDP)] is one of the most successful anticancer agents effective against a wide range of solid tumors. However, its use is restricted by side effects and/or by intrinsic or acquired drug resistance. Here, we probed the role of glutathione transferase (...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: De Luca, Anastasia, Parker, Lorien J., Ang, Wee Han, Rodolfo, Carlo, Gabbarini, Valentina, Hancock, Nancy C., Palone, Francesca, Mazzetti, Anna P., Menin, Laure, Morton, Craig J., Parker, Michael W., Lo Bello, Mario, Dyson, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6628828/
https://ncbi.nlm.nih.gov/pubmed/31221747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903297116
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