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Influence of the H-site residue 108 on human glutathione transferase P1-1 ligand binding: Structure-thermodynamic relationships and thermal stability

The effect of the Y108V mutation of human glutathione S-transferase P1-1 (hGST P1-1) on the binding of the diuretic drug ethacrynic acid (EA) and its glutathione conjugate (EASG) was investigated by calorimetric, spectrofluorimetric, and crystallographic studies. The mutation Tyr 108 → Val resulted...

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Detalhes bibliográficos
Main Authors: Quesada-Soriano, Indalecio, Parker, Lorien J, Primavera, Alessandra, Casas-Solvas, Juan M, Vargas-Berenguel, Antonio, Barón, Carmen, Morton, Craig J, Paola Mazzetti, Anna, Lo Bello, Mario, Parker, Michael W, García-Fuentes, Luis
Formato: Artigo
Idioma:Inglês
Publicado em: Wiley Subscription Services, Inc., A Wiley Company 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2821265/
https://ncbi.nlm.nih.gov/pubmed/19780048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.253
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