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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contains four structural motifs (A, B, C, and D) that are conserved in polymerases from diverse organisms. Motif B interacts with the incoming nucleotide, the template strand, and key active-site residues from other motifs, sugge...

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Bibliografiske detaljer
Main Authors: Smith, Robert A., Anderson, Donovan J., Preston, Bradley D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1489025/
https://ncbi.nlm.nih.gov/pubmed/16809322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00322-06
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