The Human Immunodeficiency Virus Type 1 Nonnucleoside Reverse Transcriptase Inhibitor Resistance Mutation I132M Confers Hypersensitivity to Nucleoside Analogs

We previously identified a rare mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), I132M, which confers high-level resistance to the nonnucleoside RT inhibitors (NNRTIs) nevirapine and delavirdine. In this study, we have further characterized the role of this mutatio...

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Detalhes bibliográficos
Main Authors: Ambrose, Zandrea, Herman, Brian D., Sheen, Chih-Wei, Zelina, Shannon, Moore, Katie L., Tachedjian, Gilda, Nissley, Dwight V., Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2663283/
https://ncbi.nlm.nih.gov/pubmed/19193782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01968-08
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