Characterization of novel non-nucleoside reverse transcriptase (RT) inhibitor resistance mutations at residues 132 and 135 in the 51 kDa subunit of HIV-1 RT

Several rare and novel NNRTI [non-nucleoside reverse transcriptase (RT) inhibitor] resistance mutations were recently detected at codons 132 and 135 in RTs from clinical isolates using the yeast-based chimaeric TyHRT (Ty1/HIV-1 RT) phenotypic assay. Ile(132) and Ile(135) form part of the β7–β8 loop...

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Main Authors: Nissley, Dwight V., Radzio, Jessica, Ambrose, Zandrea, Sheen, Chih-Wei, Hamamouch, Noureddine, Moore, Katie L., Tachedjian, Gilda, Sluis-Cremer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1868834/
https://ncbi.nlm.nih.gov/pubmed/17286555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20061814
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