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N348I in HIV-1 Reverse Transcriptase Decreases Susceptibility to Tenofovir and Etravirine in Combination with Other Resistance Mutations

We previously demonstrated that N348I in HIV-1 reverse transcriptase confers zidovudine and nevirapine resistance. However, both of these inhibitors are currently infrequently used in developed countries and the impact of N348I on newer RT inhibitors, such as tenofovir and etravirine, is unknown. In...

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Detalhes bibliográficos
Main Authors: Sluis-Cremer, Nicolas, Moore, Katie, Radzio, Jessica, Sonza, Secondo, Tachedjian, Gilda
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874243/
https://ncbi.nlm.nih.gov/pubmed/20010074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283315697
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