Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer

The specific impact of mutations that abrogate human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) dimerization on virus replication is not known, as mutations shown previously to inhibit RT dimerization also impact Gag-Pol stability, resulting in pleiotropic effects on HIV-1 repl...

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Bibliographic Details
Main Authors: Wapling, Johanna, Moore, Katie L., Sonza, Secondo, Mak, Johnson, Tachedjian, Gilda
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1182633/
https://ncbi.nlm.nih.gov/pubmed/16051818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.16.10247-10257.2005
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