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Subunit-specific mutational analysis of residue N348 in HIV-1 reverse transcriptase
BACKGROUND: N348I in HIV-1 reverse transcriptase (RT) confers resistance to zidovudine (AZT) and nevirapine. Biochemical studies demonstrated that N348I indirectly increases AZT resistance by decreasing the frequency of secondary ribonuclease H (RNase H) cleavages that reduce the RNA/DNA duplex leng...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
BioMed Central
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3168420/ https://ncbi.nlm.nih.gov/pubmed/21859446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-8-69 |
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