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N348I in HIV-1 Reverse Transcriptase Counteracts the Synergy Between Zidovudine and Nevirapine

The efficacy of regimens that include both zidovudine and nevirapine can be explained by the synergistic interactions between these drugs. N348I in HIV-1 reverse transcriptase (RT) confers decreased susceptibility to zidovudine and nevirapine. Here we demonstrate that N348I reverses the synergistic...

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Hlavní autoři: YAP, Soo Huey, Herman, Brian D., RADZIO, Jessica, SLUIS-CREMER, Nicolas, TACHEDJIAN, Gilda
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3458157/
https://ncbi.nlm.nih.gov/pubmed/22743599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e3182657990
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