N348I in the Connection Domain of HIV-1 Reverse Transcriptase Confers Zidovudine and Nevirapine Resistance

BACKGROUND: The catalytically active 66-kDa subunit of the human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) consists of DNA polymerase, connection, and ribonuclease H (RNase H) domains. Almost all known RT inhibitor resistance mutations identified to date map to the polymerase...

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Autori principali: Yap, Soo-Huey, Sheen, Chih-Wei, Fahey, Jonathan, Zanin, Mark, Tyssen, David, Lima, Viviane Dias, Wynhoven, Brian, Kuiper, Michael, Sluis-Cremer, Nicolas, Harrigan, P. Richard, Tachedjian, Gilda
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2007
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2100143/
https://ncbi.nlm.nih.gov/pubmed/18052601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.0040335
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