Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

Background: The viral RNA-dependent RNA polymerase (RdRp) enzymes of the Flaviviridae family are essential for viral replication and are logically important targets for development of antiviral therapeutic agents. Zika virus (ZIKV) is a rapidly re-emerging human pathogen for which no vaccine or anti...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Xu, Hong-Tao, Hassounah, Said A., Colby-Germinario, Susan P., Oliveira, Maureen, Fogarty, Clare, Quan, Yudong, Han, Yingshan, Golubkov, Olga, Ibanescu, Ilinca, Brenner, Bluma, Stranix, Brent R., Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890664/
https://ncbi.nlm.nih.gov/pubmed/28069884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkw514
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