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M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA
BACKGROUND: 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a potent nucleoside analogue inhibitor of HIV that has an unusually long half-life. Cell culture selections with either EFdA or lamivudine using both subtype B and non-B clinical isolates selected the M184I/V substitutions in reverse transc...
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| Publicado no: | J Antimicrob Chemother |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5890679/ https://ncbi.nlm.nih.gov/pubmed/28961903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx280 |
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