M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA

BACKGROUND: 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a potent nucleoside analogue inhibitor of HIV that has an unusually long half-life. Cell culture selections with either EFdA or lamivudine using both subtype B and non-B clinical isolates selected the M184I/V substitutions in reverse transc...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:J Antimicrob Chemother
Asıl Yazarlar: Oliveira, Maureen, Brenner, Bluma G, Xu, Hongtao, Ibanescu, Ruxandra-Ilinca, Mesplède, Thibault, Wainberg, Mark A
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890679/
https://ncbi.nlm.nih.gov/pubmed/28961903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx280
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller