M184I/V substitutions and E138K/M184I/V double substitutions in HIV reverse transcriptase do not significantly affect the antiviral activity of EFdA

BACKGROUND: 4′-Ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a potent nucleoside analogue inhibitor of HIV that has an unusually long half-life. Cell culture selections with either EFdA or lamivudine using both subtype B and non-B clinical isolates selected the M184I/V substitutions in reverse transc...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Antimicrob Chemother
Auteurs principaux: Oliveira, Maureen, Brenner, Bluma G, Xu, Hongtao, Ibanescu, Ruxandra-Ilinca, Mesplède, Thibault, Wainberg, Mark A
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5890679/
https://ncbi.nlm.nih.gov/pubmed/28961903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkx280
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