Basis for Early and Preferential Selection of the E138K Mutation in HIV-1 Reverse Transcriptase

E138K, a G→A mutation in HIV-1 reverse transcriptase (RT), is preferentially selected by etravirine (ETR) and rilpivirine over other substitutions at position E138 that offer greater drug resistance. We hypothesized that there was a mutational bias for the E138K substitution and designed an allele-s...

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Main Authors: McCallum, Matthew, Oliveira, Maureen, Ibanescu, Ruxandra-Ilinca, Kramer, Victor G., Moisi, Daniela, Asahchop, Eugene L., Brenner, Bluma G., Harrigan, P. Richard, Xu, Hongtao, Wainberg, Mark A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2013
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3811420/
https://ncbi.nlm.nih.gov/pubmed/23856772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01029-13
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