Characterization of the E138K Resistance Mutation in HIV-1 Reverse Transcriptase Conferring Susceptibility to Etravirine in B and Non-B HIV-1 Subtypes

We have selected for resistance to etravirine (ETR) and efavirenz (EFV) in tissue culture using three subtype B, three subtype C, and two CRF02_AG clinical isolates, grown in cord blood mononuclear cells. Genotypic analysis was performed at baseline and at various weeks of selection. Phenotypic resi...

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Detalhes bibliográficos
Main Authors: Asahchop, Eugene L., Oliveira, Maureen, Wainberg, Mark A., Brenner, Bluma G., Moisi, Daniela, Toni, Thomas d'Aquin, Tremblay, Cecile L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3028807/
https://ncbi.nlm.nih.gov/pubmed/21135184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01192-10
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