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Effect of HIV-1 Integrase Resistance Mutations When Introduced into SIVmac239 on Susceptibility to Integrase Strand Transfer Inhibitors

Studies on the in vitro susceptibility of SIV to integrase strand transfer inhibitors (INSTIs) have been rare. In order to determine the susceptibility of SIVmac239 to INSTIs and characterize the genetic pathways that might lead to drug resistance, we inserted various integrase (IN) mutations that h...

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Detalhes bibliográficos
Main Authors: Hassounah, Said A., Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Sandstrom, Paul A., Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136349/
https://ncbi.nlm.nih.gov/pubmed/24920794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00947-14
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