Effect of HIV-1 Integrase Resistance Mutations When Introduced into SIVmac239 on Susceptibility to Integrase Strand Transfer Inhibitors

Studies on the in vitro susceptibility of SIV to integrase strand transfer inhibitors (INSTIs) have been rare. In order to determine the susceptibility of SIVmac239 to INSTIs and characterize the genetic pathways that might lead to drug resistance, we inserted various integrase (IN) mutations that h...

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Hlavní autoři: Hassounah, Said A., Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Sandstrom, Paul A., Wainberg, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4136349/
https://ncbi.nlm.nih.gov/pubmed/24920794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00947-14
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