Biochemical Analysis of the Role of G118R-Linked Dolutegravir Drug Resistance Substitutions in HIV-1 Integrase

Drug resistance mutations (DRMs) have been reported for all currently approved anti-HIV drugs, including the latest integrase strand transfer inhibitors (INSTIs). We previously used the new INSTI dolutegravir (DTG) to select a G118R integrase resistance substitution in tissue culture and also showed...

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Bibliografiske detaljer
Main Authors: Quashie, Peter K., Mesplède, Thibault, Han, Ying-Shan, Veres, Tamar, Osman, Nathan, Hassounah, Said, Sloan, Richard D., Xu, Hong-Tao, Wainberg, Mark A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2013
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3837891/
https://ncbi.nlm.nih.gov/pubmed/24080645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01835-13
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