The R262K Substitution Combined with H51Y in HIV-1 Subtype B Integrase Confers Low-Level Resistance against Dolutegravir

Clinical studies have shown that integrase strand transfer inhibitors (INSTIs) can be used effectively against HIV-1 infection. To date, no resistance substitution has been found in INSTI-naive patients treated with the new integrase inhibitor dolutegravir (DTG). In a recent selection study with DTG...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Cutillas, Vincent, Mesplede, Thibault, Anstett, Kaitlin, Hassounah, Said, Wainberg, Mark A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2014
Témata:
Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4291366/
https://ncbi.nlm.nih.gov/pubmed/25348535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04274-14
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