Dolutegravir maintains a durable effect against HIV replication in tissue culture even after drug washout

OBJECTIVES: Of the currently approved HIV integrase strand transfer inhibitors (INSTIs), dolutegravir has shown greater efficacy than raltegravir at suppressing HIV-1 replication in treatment-experienced individuals. Biochemical experiments have also shown that dolutegravir has a longer dissociative...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Osman, Nathan, Mesplède, Thibault, Quashie, Peter K., Oliveira, Maureen, Zanichelli, Veronica, Wainberg, Mark A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4566961/
https://ncbi.nlm.nih.gov/pubmed/26142476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkv176
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