Site-selective Suzuki–Miyaura coupling of heteroaryl halides – understanding the trends for pharmaceutically important classes

por Almond-Thynne, Joshua, Blakemore, David C., Pryde, David C., Spivey, Alan C.
Publicado en Chem Sci (2017)

G10 is a direct activator of human STING

por Banerjee, Monali, Middya, Sandip, Shrivastava, Ritesh, Basu, Sourav, Ghosh, Rajib, Pryde, David C., Yadav, Dharmendra B., Surya, Arjun
Publicado en PLoS One (2020)

Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism

por Bagnéris, Claire, DeCaen, Paul G., Naylor, Claire E., Pryde, David C., Nobeli, Irene, Clapham, David E., Wallace, B. A.
Publicado 2014

Structural basis for inhibition of a voltage-gated Ca(2+) channel by Ca(2+) antagonist drugs

por Tang, Lin, Gamal El-Din, Tamer M., Swanson, Teresa M., Pryde, David C., Scheuer, Todd, Zheng, Ning, Catterall, William A.
Publicado en Nature (2016)

Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entr...

por Laxton, Carl, Brady, Kevin, Moschos, Sterghios, Turnpenny, Paul, Rawal, Jaiessh, Pryde, David C., Sidders, Ben, Corbau, Romu, Pickford, Chris, Murray, E. J.
Publicado 2011

TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype

por Tseng, Wei Chou, Pryde, David C., Yoger, Katrina E., Padilla, Karen M., Antonio, Brett M., Han, Seungil, Shanmugasundaram, Veerabahu, Gerlach, Aaron C.
Publicado en Proc Natl Acad Sci U S A (2018)

Valproic acid interactions with the NavMs voltage-gated sodium channel

por Zanatta, Geancarlo, Sula, Altin, Miles, Andrew J., Ng, Leo C. T., Torella, Rubben, Pryde, David C., DeCaen, Paul G., Wallace, B. A.
Publicado en Proc Natl Acad Sci U S A (2019)

Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads

por Oduor, Richard O., Ojo, Kayode K., Williams, Gareth P., Bertelli, Francois, Mills, James, Maes, Louis, Pryde, David C., Parkinson, Tanya, Van Voorhis, Wesley C., Holler, Tod P.
Publicado 2011

Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

por Andrews, Mark D., af Forselles, Kerry, Beaumont, Kevin, Galan, Sébastien R. G., Glossop, Paul A., Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S., Lunn, Graham, Maw, Graham, Owen, Robert M., Pryde, David C., Roberts, Dannielle, Tran, Thien Duc
Publicado en ACS Med Chem Lett (2015)

Discovery of a Series of Indazole TRPA1 Antagonists

por Pryde, David C., Marron, Brian E., West, Christopher W., Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J., Turner, Jamie, Warmus, Joseph S., Swain, Nigel A., Omoto, Kiyoyuki, Mahoney, John H., Gerlach, Aaron C.
Publicado en ACS Med Chem Lett (2017)

A Series of Potent CREBBP Bromodomain Ligands Reveals an Induced-Fit Pocket Stabilized by a Cation–π Interaction**

por Rooney, Timothy P C, Filippakopoulos, Panagis, Fedorov, Oleg, Picaud, Sarah, Cortopassi, Wilian A, Hay, Duncan A, Martin, Sarah, Tumber, Anthony, Rogers, Catherine M, Philpott, Martin, Wang, Minghua, Thompson, Amber L, Heightman, Tom D, Pryde, David C, Cook, Andrew, Paton, Robert S, Müller, Susanne, Knapp, Stefan, Brennan, Paul E, Conway, Stuart J
Publicado en Angew Chem Int Ed Engl (2014)

A Pharmacological Master Key Mechanism that Unlocks the Selectivity Filter Gate in K(+) Channels

por Schewe, Marcus, Sun, Han, Mert, Ümit, Mackenzie, Alexandra, Pike, Ashley C. W., Schulz, Friederike, Constantin, Cristina, Vowinkel, Kirsty S., Conrad, Linus J., Kiper, Aytug K., Gonzalez, Wendy, Musinszki, Marianne, Tegtmeier, Marie, Pryde, David C., Belabed, Hassane, Nazare, Marc, de Groot, Bert L., Decher, Niels, Fakler, Bernd, Carpenter, Elisabeth P., Tucker, Stephen J., Baukrowitz, Thomas
Publicado en Science (2019)

Selection of a Novel Anti-Nicotine Vaccine: Influence of Antigen Design on Antibody Function in Mice

por Pryde, David C., Jones, Lyn H., Gervais, David P., Stead, David R., Blakemore, David C., Selby, Matthew D., Brown, Alan D., Coe, Jotham W., Badland, Matthew, Beal, David M., Glen, Rebecca, Wharton, Yvonne, Miller, Gavin J., White, Phil, Zhang, Ningli, Benoit, Michelle, Robertson, Karen, Merson, James R., Davis, Heather L., McCluskie, Michael J.
Publicado 2013

11th German Conference on Chemoinformatics (GCC 2015): Fulda, Germany. 8–10 November 2015

por Fechner, Uli, de Graaf, Chris, Torda, Andrew E., Güssregen, Stefan, Evers, Andreas, Matter, Hans, Hessler, Gerhard, Richmond, Nicola J., Schmidtke, Peter, Segler, Marwin H. S., Waller, Mark P., Pleik, Stefanie, Shea, Joan-Emma, Levine, Zachary, Mullen, Ryan, van den Broek, Karina, Epple, Matthias, Kuhn, Hubert, Truszkowski, Andreas, Zielesny, Achim, Fraaije, Johannes (Hans), Gracia, Ruben Serral, Kast, Stefan M., Bulusu, Krishna C., Bender, Andreas, Yosipof, Abraham, Nahum, Oren, Senderowitz, Hanoch, Krotzky, Timo, Schulz, Robert, Wolber, Gerhard, Bietz, Stefan, Rarey, Matthias, Zimmermann, Markus O., Lange, Andreas, Ruff, Manuel, Heidrich, Johannes, Onlia, Ionut, Exner, Thomas E., Boeckler, Frank M., Bermudez, Marcel, Firaha, Dzmitry S., Hollóczki, Oldamur, Kirchner, Barbara, Tautermann, Christofer S., Volkamer, Andrea, Eid, Sameh, Turk, Samo, Rippmann, Friedrich, Fulle, Simone, Saleh, Noureldin, Saladino, Giorgio, Gervasio, Francesco L., Haensele, Elke, Banting, Lee, Whitley, David C., Oliveira Santos, Jana Sopkova-de, Bureau, Ronan, Clark, Timothy, Sandmann, Achim, Lanig, Harald, Kibies, Patrick, Heil, Jochen, Hoffgaard, Franziska, Frach, Roland, Engel, Julian, Smith, Steven, Basu, Debjit, Rauh, Daniel, Kohlbacher, Oliver, Boeckler, Frank M., Essex, Jonathan W., Bodnarchuk, Michael S., Ross, Gregory A., Finkelmann, Arndt R., Göller, Andreas H., Schneider, Gisbert, Husch, Tamara, Schütter, Christoph, Balducci, Andrea, Korth, Martin, Ntie-Kang, Fidele, Günther, Stefan, Sippl, Wolfgang, Mbaze, Luc Meva’a, Ntie-Kang, Fidele, Simoben, Conrad V., Lifongo, Lydia L., Ntie-Kang, Fidele, Judson, Philip, Barilla, Jiří, Lokajíček, Miloš V., Pisaková, Hana, Simr, Pavel, Kireeva, Natalia, Petrov, Alexandre, Ostroumov, Denis, Solovev, Vitaly P., Pervov, Vladislav S., Friedrich, Nils-Ole, Sommer, Kai, Rarey, Matthias, Kirchmair, Johannes, Proschak, Eugen, Weber, Julia, Moser, Daniel, Kalinowski, Lena, Achenbach, Janosch, Mackey, Mark, Cheeseright, Tim, Renner, Gerrit, Renner, Gerrit, Schmidt, Torsten C., Schram, Jürgen, Egelkraut-Holtus, Marion, van Oeyen, Albert, Kalliokoski, Tuomo, Fourches, Denis, Ibezim, Akachukwu, Mbah, Chika J., Adikwu, Umale M., Nwodo, Ngozi J., Steudle, Alexander, Masek, Brian B., Nagy, Stephan, Baker, David, Soltanshahi, Fred, Dorfman, Roman, Dubrucq, Karen, Patel, Hitesh, Koch, Oliver, Mrugalla, Florian, Kast, Stefan M., Ain, Qurrat U., Fuchs, Julian E., Owen, Robert M., Omoto, Kiyoyuki, Torella, Rubben, Pryde, David C., Glen, Robert, Bender, Andreas, Hošek, Petr, Spiwok, Vojtěch, Mervin, Lewis H., Barrett, Ian, Firth, Mike, Murray, David C., McWilliams, Lisa, Cao, Qing, Engkvist, Ola, Warszycki, Dawid, Śmieja, Marek, Bojarski, Andrzej J., Aniceto, Natalia, Freitas, Alex, Ghafourian, Taravat, Herrmann, Guido, Eigner-Pitto, Valentina, Naß, Alexandra, Kurczab, Rafał, Bojarski, Andrzej J., Lange, Andreas, Günther, Marcel B., Hennig, Susanne, Büttner, Felix M., Schall, Christoph, Sievers-Engler, Adrian, Ansideri, Francesco, Koch, Pierre, Stehle, Thilo, Laufer, Stefan, Böckler, Frank M., Zdrazil, Barbara, Montanari, Floriane, Ecker, Gerhard F., Grebner, Christoph, Hogner, Anders, Ulander, Johan, Edman, Karl, Guallar, Victor, Tyrchan, Christian, Ulander, Johan, Tyrchan, Christian, Klute, Wolfgang, Bergström, Fredrik, Kramer, Christian, Nguyen, Quoc Dat, Frach, Roland, Kibies, Patrick, Strohfeldt, Steven, Böttcher, Saraphina, Pongratz, Tim, Horinek, Dominik, Kast, Stefan M., Rupp, Bernd, Al-Yamori, Raed, Lisurek, Michael, Kühne, Ronald, Furtado, Filipe, van den Broek, Karina, Wessjohann, Ludger, Mathea, Miriam, Baumann, Knut, Mohamad-Zobir, Siti Zuraidah, Fu, Xianjun, Fan, Tai-Ping, Bender, Andreas, Kuhn, Maximilian A., Sotriffer, Christoph A., Zoufir, Azedine, Li, Xitong, Mervin, Lewis, Berg, Ellen, Polokoff, Mark, Ihlenfeldt, Wolf D., Ihlenfeldt, Wolf D., Pretzel, Jette, Alhalabi, Zayan, Fraczkiewicz, Robert, Waldman, Marvin, Clark, Robert D., Shaikh, Neem, Garg, Prabha, Kos, Alexander, Himmler, Hans-Jürgen, Sandmann, Achim, Jardin, Christophe, Sticht, Heinrich, Steinbrecher, Thomas B., Dahlgren, Markus, Cappel, Daniel, Lin, Teng, Wang, Lingle, Krilov, Goran, Abel, Robert, Friesner, Richard, Sherman, Woody, Pöhner, Ina A., Panecka, Joanna, Wade, Rebecca C., Bietz, Stefan, Schomburg, Karen T., Hilbig, Matthias, Rarey, Matthias, Jäger, Christian, Wieczorek, Vivien, Westerhoff, Lance M., Borbulevych, Oleg Y., Demuth, Hans-Ulrich, Buchholz, Mirko, Schmidt, Denis, Rickmeyer, Thomas, Krotzky, Timo, Kolb, Peter, Mittal, Sumit, Sánchez-García, Elsa, Nogueira, Mauro S., Oliveira, Tiago B., da Costa, Fernando B., Schmidt, Thomas J.
Publicado en J Cheminform (2016)