Discovery of a Series of Indazole TRPA1 Antagonists

[Image: see text] A series of TRPA1 antagonists is described which has as its core structure an indazole moiety. The physical properties and in vitro DMPK profiles are discussed. Good in vivo exposure was obtained with several analogs, allowing efficacy to be assessed in rodent models of inflammator...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Pryde, David C., Marron, Brian E., West, Christopher W., Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J., Turner, Jamie, Warmus, Joseph S., Swain, Nigel A., Omoto, Kiyoyuki, Mahoney, John H., Gerlach, Aaron C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467201/
https://ncbi.nlm.nih.gov/pubmed/28626530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00140
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