Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain

[Image: see text] The transient receptor potential (TRP) family of ion channels comprises nonselective cation channels that respond to a wide range of chemical and thermal stimuli. TRPM8, a member of the melastatin subfamily, is activated by cold temperatures (<28 °C), and antagonists of this cha...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Andrews, Mark D., af Forselles, Kerry, Beaumont, Kevin, Galan, Sébastien R. G., Glossop, Paul A., Grenie, Mathilde, Jessiman, Alan, Kenyon, Amy S., Lunn, Graham, Maw, Graham, Owen, Robert M., Pryde, David C., Roberts, Dannielle, Tran, Thien Duc
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394344/
https://ncbi.nlm.nih.gov/pubmed/25893043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500479v
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