Valproic acid interactions with the NavMs voltage-gated sodium channel

Valproic acid (VPA) is an anticonvulsant drug that is also used to treat migraines and bipolar disorder. Its proposed biological targets include human voltage-gated sodium channels, among other membrane proteins. We used the prokaryotic NavMs sodium channel, which has been shown to be a good exempla...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Zanatta, Geancarlo, Sula, Altin, Miles, Andrew J., Ng, Leo C. T., Torella, Rubben, Pryde, David C., DeCaen, Paul G., Wallace, B. A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936711/
https://ncbi.nlm.nih.gov/pubmed/31822620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1909696116
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