Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site

We have screened 47 locked nucleic acid (LNA) antisense oligonucleotides (ASOs) targeting conserved (>95% homology) sequences in the hepatitis C virus (HCV) genome using the subgenomic HCV replicon assay and generated both antiviral (50% effective concentration [EC(50)]) and cytotoxic (50% cytoto...

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Bibliografske podrobnosti
Main Authors: Laxton, Carl, Brady, Kevin, Moschos, Sterghios, Turnpenny, Paul, Rawal, Jaiessh, Pryde, David C., Sidders, Ben, Corbau, Romu, Pickford, Chris, Murray, E. J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2011
Teme:
Antiviral Agents
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3122463/
https://ncbi.nlm.nih.gov/pubmed/21502629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00222-11
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