Uptake, Efficacy, and Systemic Distribution of Naked, Inhaled Short Interfering RNA (siRNA) and Locked Nucleic Acid (LNA) Antisense

Antisense oligonucleotides (ASOs) and small interfering RNA (siRNA) promise specific correction of disease-causing gene expression. Therapeutic implementation, however, has been forestalled by poor delivery to the appropriate tissue, cell type, and subcellular compartment. Topical administration is...

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Detalhes bibliográficos
Main Authors: Moschos, Sterghios A, Frick, Manfred, Taylor, Bruce, Turnpenny, Paul, Graves, Helen, Spink, Karen G, Brady, Kevin, Lamb, David, Collins, David, Rockel, Thomas D, Weber, Markus, Lazari, Ovadia, Perez-Tosar, Luis, Fancy, Sally A, Lapthorn, Chris, Green, Martin X, Evans, Steve, Selby, Matthew, Jones, Gareth, Jones, Lyn, Kearney, Sarah, Mechiche, Houria, Gikunju, Diana, Subramanian, Romesh, Uhlmann, Eugen, Jurk, Marion, Vollmer, Jörg, Ciaramella, Giuseppe, Yeadon, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242665/
https://ncbi.nlm.nih.gov/pubmed/21971426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.206
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