Deep Sequencing Insights in Therapeutic shRNA Processing and siRNA Target Cleavage Precision

TT-034 (PF-05095808) is a recombinant adeno-associated virus serotype 8 (AAV8) agent expressing three short hairpin RNA (shRNA) pro-drugs that target the hepatitis C virus (HCV) RNA genome. The cytosolic enzyme Dicer cleaves each shRNA into multiple, potentially active small interfering RNA (siRNA)...

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Detalhes bibliográficos
Main Authors: Denise, Hubert, Moschos, Sterghios A., Sidders, Benjamin, Burden, Frances, Perkins, Hannah, Carter, Nikki, Stroud, Tim, Kennedy, Michael, Fancy, Sally-Ann, Lapthorn, Cris, Lavender, Helen, Kinloch, Ross, Suhy, David, Corbau, Romu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951910/
https://ncbi.nlm.nih.gov/pubmed/24496437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.73
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