Safe, Long-term Hepatic Expression of Anti-HCV shRNA in a Nonhuman Primate Model

The hepatitis C virus (HCV) chronically infects 2% of the world population and effective treatment is limited by long duration and significant side-effects. Here, we describe a novel drug, intended as a “single-shot ” therapy, which expresses three short hairpin RNAs (shRNAs) that simultaneously tar...

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Detalhes bibliográficos
Main Authors: Suhy, David A, Kao, Shih-Chu, Mao, Tin, Whiteley, Laurence, Denise, Hubert, Souberbielle, Bernard, Burdick, Andrew D, Hayes, Kyle, Wright, J Fraser, Lavender, Helen, Roelvink, Peter, Kolykhalov, Alexander, Brady, Kevin, Moschos, Sterghios A, Hauck, Bernd, Zelenaia, Olga, Zhou, Shangzhen, Scribner, Curt, High, Katherine A, Renison, Sara H, Corbau, Romu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437581/
https://ncbi.nlm.nih.gov/pubmed/22735378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.119
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