PEI-complexed LNA antiseeds as miRNA inhibitors

Antisense inhibition of oncogenic or other disease-related miRNAs and miRNA families in vivo may provide novel therapeutic strategies. However, this approach relies on the development of potent miRNA inhibitors and their efficient delivery into cells. Here, we introduce short seed-directed LNA oligo...

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Detalhes bibliográficos
Main Authors: Thomas, Maren, Lange-Grünweller, Kerstin, Dayyoub, Eyas, Bakowsky, Udo, Weirauch, Ulrike, Aigner, Achim, Hartmann, Roland K., Grünweller, Arnold
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2012
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551863/
https://ncbi.nlm.nih.gov/pubmed/22894918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.21165
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