PEI-complexed LNA antiseeds as miRNA inhibitors

Antisense inhibition of oncogenic or other disease-related miRNAs and miRNA families in vivo may provide novel therapeutic strategies. However, this approach relies on the development of potent miRNA inhibitors and their efficient delivery into cells. Here, we introduce short seed-directed LNA oligo...

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Bibliografske podrobnosti
Main Authors: Thomas, Maren, Lange-Grünweller, Kerstin, Dayyoub, Eyas, Bakowsky, Udo, Weirauch, Ulrike, Aigner, Achim, Hartmann, Roland K., Grünweller, Arnold
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551863/
https://ncbi.nlm.nih.gov/pubmed/22894918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.21165
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