PEI-complexed LNA antiseeds as miRNA inhibitors

Antisense inhibition of oncogenic or other disease-related miRNAs and miRNA families in vivo may provide novel therapeutic strategies. However, this approach relies on the development of potent miRNA inhibitors and their efficient delivery into cells. Here, we introduce short seed-directed LNA oligo...

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Hlavní autoři: Thomas, Maren, Lange-Grünweller, Kerstin, Dayyoub, Eyas, Bakowsky, Udo, Weirauch, Ulrike, Aigner, Achim, Hartmann, Roland K., Grünweller, Arnold
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2012
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3551863/
https://ncbi.nlm.nih.gov/pubmed/22894918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/rna.21165
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