Trypanosoma brucei Glycogen Synthase Kinase-3, A Target for Anti-Trypanosomal Drug Development: A Public-Private Partnership to Identify Novel Leads

BACKGROUND: Trypanosoma brucei, the causative agent of Human African Trypanosomiasis (HAT), expresses two proteins with homology to human glycogen synthase kinase 3β (HsGSK-3) designated TbruGSK-3 short and TbruGSK-3 long. TbruGSK-3 short has previously been validated as a potential drug target and...

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Bibliographic Details
Main Authors: Oduor, Richard O., Ojo, Kayode K., Williams, Gareth P., Bertelli, Francois, Mills, James, Maes, Louis, Pryde, David C., Parkinson, Tanya, Van Voorhis, Wesley C., Holler, Tod P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3071371/
https://ncbi.nlm.nih.gov/pubmed/21483717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001017
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