A Pharmacological Master Key Mechanism that Unlocks the Selectivity Filter Gate in K(+) Channels

Potassium channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) that bypass the specific mechanisms but act as master k...

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Detaylı Bibliyografya
Yayımlandı:Science
Asıl Yazarlar: Schewe, Marcus, Sun, Han, Mert, Ümit, Mackenzie, Alexandra, Pike, Ashley C. W., Schulz, Friederike, Constantin, Cristina, Vowinkel, Kirsty S., Conrad, Linus J., Kiper, Aytug K., Gonzalez, Wendy, Musinszki, Marianne, Tegtmeier, Marie, Pryde, David C., Belabed, Hassane, Nazare, Marc, de Groot, Bert L., Decher, Niels, Fakler, Bernd, Carpenter, Elisabeth P., Tucker, Stephen J., Baukrowitz, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982535/
https://ncbi.nlm.nih.gov/pubmed/30792303
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav0569
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