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A Pharmacological Master Key Mechanism that Unlocks the Selectivity Filter Gate in K(+) Channels
Potassium channels have been evolutionarily tuned for activation by diverse biological stimuli, and pharmacological activation is thought to target these specific gating mechanisms. Here we report a class of negatively charged activators (NCAs) that bypass the specific mechanisms but act as master k...
Shranjeno v:
| izdano v: | Science |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6982535/ https://ncbi.nlm.nih.gov/pubmed/30792303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aav0569 |
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