A Non-canonical Voltage-Sensing Mechanism Controls Gating in K2P K(+) Channels

Two-pore domain (K2P) K(+) channels are major regulators of excitability that endow cells with an outwardly rectifying background “leak” conductance. In some K2P channels, strong voltage-dependent activation has been observed, but the mechanism remains unresolved because they lack a canonical voltag...

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Pubblicato in:Cell
Autori principali: Schewe, Marcus, Nematian-Ardestani, Ehsan, Sun, Han, Musinszki, Marianne, Cordeiro, Sönke, Bucci, Giovanna, de Groot, Bert L., Tucker, Stephen J., Rapedius, Markus, Baukrowitz, Thomas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4771873/
https://ncbi.nlm.nih.gov/pubmed/26919430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.02.002
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