Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K(+) channel

Two-pore domain K(+) (K2P) channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/KCNK1) K2P channel remain poorly characterized because heterologous expression of this ion channel yields only very low levels of functional activity. Several und...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Biol Chem
Egile Nagusiak: Nematian-Ardestani, Ehsan, Abd-Wahab, Firdaus, Chatelain, Franck C., Sun, Han, Schewe, Marcus, Baukrowitz, Thomas, Tucker, Stephen J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2020
Gaiak:
Molecular Biophysics
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956551/
https://ncbi.nlm.nih.gov/pubmed/31806709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.010612
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