Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder

nork Friedrich, Corinna, Rinné, Susanne, Zumhagen, Sven, Kiper, Aytug K, Silbernagel, Nicole, Netter, Michael F, Stallmeyer, Birgit, Schulze-Bahr, Eric, Decher, Niels
Argitaratua 2014

Functional mutagenesis screens reveal the ‘cap structure’ formation in disulfide-bridge free TASK channels

nork Goldstein, Matthias, Rinné, Susanne, Kiper, Aytug K., Ramírez, David, Netter, Michael F., Bustos, Daniel, Ortiz-Bonnin, Beatriz, González, Wendy, Decher, Niels
Argitaratua izan da Sci Rep (2016)

Structure/Activity Analysis of TASK-3 Channel Antagonists Based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine

nork Ramírez, David, Bedoya, Mauricio, Kiper, Aytug K., Rinné, Susanne, Morales-Navarro, Samuel, Hernández-Rodríguez, Erix W., Sepúlveda, Francisco V., Decher, Niels, González, Wendy
Argitaratua izan da Int J Mol Sci (2019)

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening

nork Ramírez, David, Concha, Guierdy, Arévalo, Bárbara, Prent-Peñaloza, Luis, Zúñiga, Leandro, Kiper, Aytug K., Rinné, Susanne, Reyes-Parada, Miguel, Decher, Niels, González, Wendy, Caballero, Julio
Argitaratua izan da Int J Mol Sci (2019)

An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities

nork Wemhöner, Konstantin, Kanyshkova, Tatyana, Silbernagel, Nicole, Fernandez-Orth, Juncal, Bittner, Stefan, Kiper, Aytug K., Rinné, Susanne, Netter, Michael F., Meuth, Sven G., Budde, Thomas, Decher, Niels
Argitaratua izan da Front Mol Neurosci (2015)

5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis

nork Ramírez, David, Mejia-Gutierrez, Melissa, Insuasty, Braulio, Rinné, Susanne, Kiper, Aytug K., Platzk, Magdalena, Müller, Thomas, Decher, Niels, Quiroga, Jairo, De-la-Torre, Pedro, González, Wendy
Argitaratua izan da Molecules (2021)

The molecular basis for an allosteric inhibition of K(+)-flux gating in K(2P) channels

nork Rinné, Susanne, Kiper, Aytug K, Vowinkel, Kirsty S, Ramírez, David, Schewe, Marcus, Bedoya, Mauricio, Aser, Diana, Gensler, Isabella, Netter, Michael F, Stansfeld, Phillip J, Baukrowitz, Thomas, Gonzalez, Wendy, Decher, Niels
Argitaratua izan da eLife (2019)

Sodium permeable and “hypersensitive” TREK‐1 channels cause ventricular tachycardia

nork Decher, Niels, Ortiz‐Bonnin, Beatriz, Friedrich, Corinna, Schewe, Marcus, Kiper, Aytug K, Rinné, Susanne, Seemann, Gunnar, Peyronnet, Rémi, Zumhagen, Sven, Bustos, Daniel, Kockskämper, Jens, Kohl, Peter, Just, Steffen, González, Wendy, Baukrowitz, Thomas, Stallmeyer, Birgit, Schulze‐Bahr, Eric
Argitaratua izan da EMBO Mol Med (2017)

A Pharmacological Master Key Mechanism that Unlocks the Selectivity Filter Gate in K(+) Channels

nork Schewe, Marcus, Sun, Han, Mert, Ümit, Mackenzie, Alexandra, Pike, Ashley C. W., Schulz, Friederike, Constantin, Cristina, Vowinkel, Kirsty S., Conrad, Linus J., Kiper, Aytug K., Gonzalez, Wendy, Musinszki, Marianne, Tegtmeier, Marie, Pryde, David C., Belabed, Hassane, Nazare, Marc, de Groot, Bert L., Decher, Niels, Fakler, Bernd, Carpenter, Elisabeth P., Tucker, Stephen J., Baukrowitz, Thomas
Argitaratua izan da Science (2019)

The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function

nork Silbernagel, Nicole, Walecki, Magdalena, Schäfer, Martin K.-H., Kessler, Mirjam, Zobeiri, Mehrnoush, Rinné, Susanne, Kiper, Aytug K., Komadowski, Marlene A., Vowinkel, Kirsty S., Wemhöner, Konstantin, Fortmüller, Lisa, Schewe, Marcus, Dolga, Amalia M., Scekic-Zahirovic, Jelena, Matschke, Lina A., Culmsee, Carsten, Baukrowitz, Thomas, Monassier, Laurent, Ullrich, Nina D., Dupuis, Luc, Just, Steffen, Budde, Thomas, Fabritz, Larissa, Decher, Niels
Argitaratua izan da FASEB J (2018)