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Functional mutagenesis screens reveal the ‘cap structure’ formation in disulfide-bridge free TASK channels
Two-pore-domain potassium (K(2P)) channels have a large extracellular cap structure formed by two M1-P1 linkers, containing a cysteine for dimerization. However, this cysteine is not present in the TASK-1/3/5 subfamily. The functional role of the cap is poorly understood and it remained unclear whet...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4726246/ https://ncbi.nlm.nih.gov/pubmed/26794006 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep19492 |
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