An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities

Rats of the Wistar Albino Glaxo/Rij (WAG/Rij) strain show symptoms resembling human absence epilepsy. Thalamocortical neurons of WAG/Rij rats are characterized by an increased HCN1 expression, a negative shift in I(h) activation curve, and an altered responsiveness of I(h) to cAMP. We cloned HCN1 ch...

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Detalhes bibliográficos
Publicado no:Front Mol Neurosci
Main Authors: Wemhöner, Konstantin, Kanyshkova, Tatyana, Silbernagel, Nicole, Fernandez-Orth, Juncal, Bittner, Stefan, Kiper, Aytug K., Rinné, Susanne, Netter, Michael F., Meuth, Sven G., Budde, Thomas, Decher, Niels
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4630678/
https://ncbi.nlm.nih.gov/pubmed/26578877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2015.00063
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